£2.1 million for kidney transplant study

MRI scan of kidney

The MRC Centre for Transplantation has been awarded a £2.1 million grant from the Medical Research Council (MRC), to fund a three year clinical study into the efficacy of the drug Mirococept in renal transplantation. 

Last year, the team at King’s announced that it had developed a technique to extend the life of a donor kidney; this involves perfusing the organ in a solution of Mirococept during the transfer from the donor to the recipient. Mirococept is engineered to stick within the organ during this process. The drug limits the action of a part of the immune system, known as the ‘complement’ system, which would normally attack and attempt to destroy cells from any intruder organism, including the cells of a donor organ. This is the first major clinical investigation into the usefulness of therapeutic regulation of the complement system in human renal transplantation using this approach, which could ultimately lead to extending the life of kidney transplants.  Professor Steven Sacks, director of the Centre, said: ‘The MRC has made it possible for us to try a completely new approach to protect donor kidneys at the time of transplantation, offering better prospect for a successful kidney treatment.’ King's College London is one of the top 25 universities in the world (2010 QS international world rankings), The Sunday Times 'University of the Year 2010/11' and the fourth oldest in England. A research-led university based in the heart of London, King's has nearly 23,000 students (of whom more than 8,600 are graduate students) from nearly 140 countries, and some 5,500 employees. King's is in the second phase of a £1 billion redevelopment programme which is transforming its estate.  King's has an outstanding reputation for providing world-class teaching and cutting-edge research. In the 2008 Research Assessment Exercise for British universities, 23 departments were ranked in the top quartile of British universities; over half of our academic staff work in departments that are in the top 10 per cent in the UK in their field and can thus be classed as world leading. The College is in the top seven UK universities for research earnings and has an overall annual income of nearly £450 million.  King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar. It is the largest centre for the education of healthcare professionals in Europe; no university has more Medical Research Council Centres.  King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: http://www.kingshealthpartners.org/.  For further information please contact Emma Reynolds, Press Officer at King’s College London, on 0207 848 4334 or email emma.reynolds@kcl.ac.uk

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